Conférence CRCHUM – Chris Donnelly, Ph. D.

Heure : 12h
Lieu : Amphithéâtre du CENTRE DE RECHERCHE DU CHUM, Pavillon R
Adresse : 900, rue Saint-Denis, 5e étage


Meeting ID: 821 2254 7648
Passcode: 356033

Chris Donnelly, Ph. D.
Assistant Professor
Scientific Director-LiveLikeLou Center for ALS Research
Department of Neurobiology
University of Pittsburgh

Titre : Pathogenic TDP-43 interactions in ALS/FTLD

TDP-43 is a critical RNA binding protein found mislocalized in neurons of patient’s diagnosed with amyotrophic lateral sclerosis (ALS/MND), frontotemporal lobar degeneration (FTLD), and related dementias. Recent work indicates that TDP-43 undergoes liquid-liquid phase separation into biomolecular condensates, and this is required for maintaining its solubility and function under physiological conditions. In disease states, TDP-43 is subject to pathological/aberrant phase transitions resulting in both nuclear loss-of-function and cytoplasmic gain-of-function events. Here, we will highlight work identifying TDP-43 interactors that drive physiological and pathogenic phase transitions. These include novel RNA species and nuclear proteins that can regulate TDP-43 function, solubility, and toxicity.

Invité de Christine Vande Velde

Axe Neurosciences