Conférence scientifique du vendredi midi

Date : 25 novembre 2022
Heure : 12h à 13h
Lieu : Amphithéâtre Justine-Lacoste-Beaubien

Pour l’axe Cerveau et développement de l’enfant



Zhou Yang, PhD

Montreal Neurological Institute
Department of Neurology and Neurosurgery
Faculty of Medicine and Health Sciences, McGill University

Modeling and testing therapeutic gene editing for neurodevelopmental disorders 

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Neurodevelopmental disorders (NDDs) such as Autism Spectrum Disorders (ASD), Intellectual Disability (ID), Epilepsy, are prevalent, heterogeneous conditions that are often associated with gene mutations. Mutation or disruption of gene(s) encoding protein(s) implicated in communication between neurons represents highly penetrant, monogenic risk factors for NDDs. Recent advances in gene editing enabled the creation of genetically engineered mouse and non-human primate (NHP) models of NDDs. Such models allow for gaining a better neurobiological understanding of NDDs and testing pre-clinical therapeutic strategies. I will provide a personal perspective on correcting mutated gene(s) in the nervous system and alleviating neural and behavioral deficits resulting from NDDs. I will present collaborative efforts during my postdoctoral training on generating and characterizing SHANK3 mutant mice and monkey models of NDDs. I will introduce an ongoing project using mouse genetics to reveal the role of NDD-associated genes in the brain. I will briefly introduce ongoing technology development in the lab and a proof-of-concept test of gene therapy in animal models of neurodevelopmental disorders.

Entrée libre

Date Conférencier Présentation Axe
2 déc. Suzanne P. Ribeiro À venir Maladies infectieuses et soins aigus
9 déc. Guillaume Émeriaud Conclusions de la 2e conférence de consensus sur la définition et la prise en charge du syndrome de détresse respiratoire aigu de l’enfant (PALICC-2) Maladies infectieuses et soins aigus