Adriana Di Polo

Adriana Di Polo

Professeure titulaire
514 890-8000, postes 31280 et 31287
Courriel – Site Web

Adresse
CRCHUM, Tour Viger
900, rue St-Denis, R09.480
Montréal (Québec)  H2X 0A9

Thème (s)

  • Mécanismes moléculaires de mort neuronale dans le système visuel endommagé;
  • Interactions neurone-glie dans la rétine;
  • Mise au point de nouvelles thérapies pour les maladies de perte de vision.

Publications choisies

  • Lebrun-Julien, F., Duplan, L., Pernet, V., Osswald, I., Bourgeois, P., Sapieha, P.S., Dickson,K., Bowie, D., Barker, P.A., Di Polo, A. (2009) Excitotoxic death of retinal neurons in vivo occurs via a non cell-autonomous mechanism. J Neuroscience 29:5536-45. Article was chosen for highlight commentary by the Editor;
  • ProNGF induces TNFalpha-dependent death of retinal ganglion cells through a p75NTR non-cell-autonomous signaling pathway. (2010) Lebrun-Julien F., Bertrand M.J., De Backer O., Stellwagen D., Morales C.R., Di Polo A., Barker P.A. Proc Natl Acad Sci U S A. 107:3817-3822;
  • Almasieh, M., Zhou, Y., Kelly, M., Casanova, C., Di Polo, A. (2010) Structural and functional neuroprotection in glaucoma: role of galantamine-mediated activation of muscarinic acetylcholine receptors. Cell Death & Dis 1: e27.  Article was chosen for commentary;
  • Almasieh, M., Lieven, C., Levin, L.A., Di Polo, A. (2011) Cell-permeable phosphine-borane compounds delay retinal ganglion cell death after acute and chronic axonal injury. J Neurochem 118:1075-1086;
  •  Wilson AM, Di Polo A. (2012) Gene therapy for retinal ganglion cell neuroprotection in glaucoma. Gene Ther. 19:127-36;
  • Almasieh, M., Wilson, A.M. Morquette, B., Cueva-Vargas, J.L., Di Polo, A. (2012) The molecular basis of retinal ganglion cell death in glaucoma. Prog Ret Eye Res 31: 152-181. Most downloaded review article since March 2012;
  • Wilson, A.M., Morquette, B., Abdouh, M., Unsain, N., Barker, P.A., Feinstein, E., Bernier, G., Di Polo, A. (2013) ASPP1/2 regulate p53-dependent death of retinal ganglion cells through PUMA and Fas/CD95 activation in vivo. J Neurosci 33: 2205-2216;
  •  Almasieh, M., MacIntyre, J.N., Pouliot, M., Casanova, C., Vaucher, E., Kelly, M.E.M., Di Polo, A.  (2013) Acetylcholinesterase inhibition promotes retinal vasoprotection and increases ocular blood flow in experimental glaucoma. Invest Ophthalmol & Vis Sci 54: 3171-3183.
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