Graziella Di Cristo

Professeure agrégée
514 345-4931, poste 2867
514 345-4801 (télécopieur)
Courriel

Adresse physique
Centre de Recherche, CHU Ste-Justine
Local 3.17.005
3175, chemin de la Côte-Ste-Catherine
Montréal (Québec)  H3T 1C5

Adresse postale
Département de neurosciences
Faculté de médecine
Université de Montréal
C.P. 6128, Succ. Centre-ville
Montréal (Québec) H3C 3J7

Thème (s)

  • Voies moléculaires impliquées dans la maturation des circuits GABAergiques dans le cerveau postnatal ;
  • Plasticité des circuits corticaux en développement ;
  • Troubles d’apprentissage dans des modèles animaux de maladies neurodéveloppementales (déficience intellectuelle, autisme).

Publications choisies

  • Di Cristo G, Chattopadhyaya B, Kuhlman SJ, Fu Y, Bélanger M-C, Wu CZ Rutishauser U, Maffei L, Huang ZJ (2007). Activity-dependent PSA expression promotes the maturation of GABA inhibition and the onset of critical period plasticity. Nature Neuroscience, 10:1569-1577.
    • Baho E, Di Cristo G (2012). Neural activity and neurotransmission regulate the maturation of innervation field of cortical GABAergic interneurons in an age-dependent manner. Journal of Neuroscience,  32(3): 911-918.
      • Chattopadhyaya B, Baho E, Huang JZ, Schachner M, Di Cristo G (2013). Neural cell adhesion molecule-mediated Fyn activation promotes GABAergic synapse maturation in postnatal mouse cortex. Journal of Neuroscience, 33:5957-68.
        • Berryer MH, Hamdan FF, Klitten LL, Møller RS, Carmant L, Schwartzentruber J, Patry L, Dobrzeniecka S, Rochefort D, Neugnot-Cerioli M, Lacaille JC, Niu Z, Eng CM, Yang Y, Palardy S, Belhumeur C, Rouleau GA, Tommerup N, Immken L, Beauchamp MH, Patel GS, Majewski J, Tarnopolsky MA, Scheffzek K, Hjalgrim H, Michaud JL,Di Cristo G (2013). Mutations in SYNGAP1 cause intellectual disability, autism and a specific form of epilepsy by inducing haploinsufficiency. Human Mutations 34:385-94.
          • Lachance-Touchette P*, Choudhury M*, Stoica A, Di Cristo G, Cossette P (2014). Single-cell genetic expression of mutant GABAA receptors causing Human genetic epilepsy alters dendritic spine and GABAergic bouton formation in a mutation-specific manner. Frontiers in Cellular Neuroscience, 14;8:317. doi: 10.3389/fncel.2014.00317. * equal contribution.
            • Awad PN, Sanon N, Chattopadhyaya B, Carriço JN, Ouardouz M, Gagné J, Duss S, Wolf D, Desgent S, Cancedda L, Carmant L, Di Cristo G (2016). Reducing premature KCC2 expression rescues seizure susceptibility and spine morphology in atypical febrile seizures. .Neurobiology of Diseases, 91:10-20.
              • Berryer MH, Chattopadhyaya B, Xing P, Riebe I, Bosoi C, Sanon N, Antoine-Bertrand J, Lévesque M, Avoli M, Hamdan FF, Carmant L, Lamarche-Vane N, Lacaille JC, Michaud JL,Di Cristo G. (2016). Decrease of SYNGAP1 in GABAergic cells impairs inhibitory synapse connectivity, synaptic inhibition and cognitive function. Nature Communications, 7:13340.
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