Adriana Di Polo

Thème (s)

• Mécanismes moléculaires de mort neuronale dans le système visuel endommagé;
• Interactions neurone-glie dans la rétine;
• Mise au point de nouvelles thérapies pour les maladies de perte de vision.

Publications choisies

• Quintero H, Shiga Y, Belforte N, Alarcon-Martinez L, El-Hajji S, Villafranca-Baughman D, Dotigny F, Di Polo A. (2022) Restoration of mitochondria axonal transport by adaptor Disc1 supplementation prevents neurodegeneration and rescues visual function. Cell Reports, 40:111324. PMID: 36103832.
• Alarcon-Martinez L, Shiga Y, Villafranca-Baughman D, Belforte N, Quintero H, Dotigny F, Cueva Vargas JL, Di Polo A. (2022) Pericyte dysfunction and loss of inter-pericyte tunneling nanotubes promote neurovascular deficits in glaucoma. Proceedings of the Academy of Sciences USA 119:e2110329119. PMID: 35135877.
• Belforte N, Agostinone J, Alarcon-Martinez L, Dotigny F, Cueva-Vargas JL, Di Polo A. (2021) AMPK hyperactivation promotes dendrite retraction, synaptic loss, and neuronal dysfunction in glaucoma. Molecular Neurodegeneration, 16:43. PMID: 34187514.
• Alarcon-Martinez L, Villafranca-Baughman D, Quintero H, Kacerovsky JB, Dotigny F, Murai KK, Prat A, Drapeau P, Di Polo A. (2020) Interpericyte tunnelling nanotubes regulate neurovascular coupling. Nature, 585:91-95. Article selected for commentary in News & Views. PMID: 32788726.
• Agostinone J, Alarcon-Martinez L, Gamlin C, Yu W-Q, Wong ROL, Di Polo A. (2018) Insulin signaling promotes dendrite and synapse regeneration and restores circuit function after axonal injury. Brain, 141: 1963-1980. PMID: 29931057.