Gilbert Bernier

Thème (s)

• Mécanismes moléculaires de contrôle du vieillissement des neurones dans le cerveau et la rétine chez l’homme et la souris : Implication dans les maladies neurodégénératives associées à l’âge;
• Étude des mécanismes de différentiation et de survie des photorécepteurs;
• Utilisation des cellules souches embryonnaires humaines pour la production et la transplantation de photorécepteurs dans le traitement des maladies dégénératives de la rétine.

Publications choisies

• Anthony Flamier¹, Jida El Hajjar¹, James Adjaye ², Karl J. Fernandes ^{3, 4}, Mohamed Abdouh¹, and Gilbert Bernier^{1, 4,} (2018). Modeling late-onset sporadic Alzheimer’s disease through BMI1 deficiency. Cell Reports. 23: 2653-2666;
• Khalili S1, Ballios BG2, Belair-Hickey J1, Donaldson L3, Liu J1, Coles BLK1, Grisé KN1, Baakdhah T, Bader GD, Wallace VA, Bernier G, Shoichet MS, van der Kooy D (2018). Induction of rod versus cone photoreceptor-specific progenitors from retinal precursor cells. Stem Cell Res. Dec;33:215-227. doi: 10.1016/j.scr.2018.11.005;
• El Hajjar J1, Chatoo W1, Hanna R1, Nkanza P1, Tétreault N1, Tse YC2,3, Wong TP2,3, Abdouh M1, Bernier G (2019). Heterochromatic genome instability and neurodegeneration sharing similarities with Alzheimer’s disease in old Bmi1+/- mice. Scientific Reports. Jan 24;9(1):594. doi: 10.1038/s41598-018-37444-3;
• Anthony Flamier^1†, Mohamed Abdouh^1†, Rimi Hamam¹, Andrea Barabino¹, Niraj Patel¹, Andy Gao¹, Roy Hanna¹ and Gilbert Bernier^{1, 2*} (2020). Off-target effect of the BMI1 inhibitor PTC596 drives epithelial-mesenchymal transition in glioblastoma multiforme. NPG Precision Oncology. Jan 6; 4:1. doi: 10.1038/s41698-019-0106-1;
• Barabino, A., Flamier, Hanna, R., A., Héon, E., Freedman, B. S., and Bernier, G. (2020). Deregulation of neuro-developmental genes and primary cilium cytoskeleton anomalies in iPSC retinal sheets from human syndromic ciliopathies. Stem Cell Reports. 14 ; 357-373;
• Ryan Hogan, Anthony Flamier, Eleonora Nardini and Gilbert Bernier (2020). Invited Review:The Role of BMI1 in Late-Onset Sporadic Alzheimer’s Disease. Genes, 11(7), 825; doi:10.3390/genes11070825;
• Eleonora Nardini, Ryan Hogan, Anthony Flamier, and Gilbert Bernier (2021). Invited Review: Alzheimer’s disease: A tale of two disease? Neural Regeneration Research, In Press;
• Popovic^, N, Hooker^, E, Barabino^, A, Flamier, A, Provost, F, Buscarlet, B, Bernier, G (Co-PI) and Larrivée, B (2021). COCO/DAND5 inhibits developmental and pathological ocular angiogenesis. EMBO Mol. Med., In Press. DOI: 10.15252/emmm.202012005;
• Roy Hanna¹, Anthony Flamier^1,2, Andrea Barabino¹, and Gilbert Bernier^1,3 (2021) G-quadruplexes originating from evolutionary conserved L1 elements interfere with neuronal gene expression in Alzheimer’s disease. Second Revision in Nature Communications, In Press.