ADRIANA Di POLO

Thème (s)

• Mécanismes moléculaires de mort neuronale dans le système visuel endommagé;
• Interactions neurone-glie dans la rétine;
• Mise au point de nouvelles thérapies pour les maladies de perte de vision.

Publications choisies

• Lebrun-Julien, F., Duplan, L., Pernet, V., Osswald, I., Bourgeois, P., Sapeha, P.S., Dickson, K., Bowie, D., Barker, P.A., Di Polo, A. (2009) Excitotoxic death of retinal neurons in vivo occurs via a non cell-autonomous mechanism. J. Neuroscience 29:5536-45. Article was chosen for highlight commentary by the editor.
• ProNGF induces TNFalpha-dependent death of retinal ganglion cells trough a p75NTR non-cell-autonomous signaling pathway. (2010) Lebrun-Julien F., Bertrand M.J., De Backer O., Stellwagen D., Morales C.R., Di Polo A., Barker P.A. Proc Natl Acad Sci USA. 107:3817-3822.
• Almasieh, M., Zhou, Y., Kelly, M., Casanova, C., Di Polo, A. (2010) Structural and functional neuroprotection in glaucoma: role of galantamine-mediated activation of muscarinic acetylcholine receptors. Cell Death & Dis 1: e27. Article was chosen for commentary.
• Almasieh, M., Lieven, C., Levin, L.A., Di Polo, A. (2011) Cell-permeable phosphine-borane compounds delay retinal ganglion cell death after acute and chronic axonal injury. J Neurochem 118: 1075-1086.
• Wilson, AM, Di Polo, A. (2012) Gene therapy for retinal ganglion cell neuroprotection in glaucoma. Gene Ther.19:127-36.
• Almasieh, M., Wilson, A.M., Morquette, B., Cueva-Vargas, J.L., Di Polo, A. (2012) The molecular basis of retinal ganglion cell death in glaucoma. Prog Ret Eye Res 31: 152-181. Most downloaded review article since March 2012.
• Wilson, A.M., Morquette, B., Abdouh, M., Unsain, N., Barker, P.A., Feinstein, E., Bernier, G., Di Polo, A. (2013) ASPP1/2 regulate p53-dependent death of retinal ganglion cells trough PUMA and Fas/CD95 activation in vivo. J Neurosci 33: 2205-2216.
• Almasieh, M., Maclntyre, J.N., Pouliot, M., Cassanova, C., Vaucher, E., Kelly, M.E.M., Di Polo, A. (2013) Acetylcholinesterase inhibition promotes retinal vasoprotection and increases ocular blood flow in experimental glaucoma. Invest Ophthalmol & Vis Sci 54: 3171-3183.