Karl Fernandes

Thème (s)

• Cellules souches du cerveau : régulation pendant le vieillissement et la maladie d’Alzheimer;
• Cellules souches de l’hippocampe : régulation par l’exercice physique et stimulation cognitive;
• Cellules souches de la moelle épinière : identification, caractérisation, et réponses au traumatismes/maladies.

Publications choisies

• Paliouras GN, Hamilton LK, Aumont A, Joppé SE, Barnabé-Heider F, Fernandes KJL (2012). mTOR signaling is a key regulator of the transit-amplifying progenitor pool in the adult and aging forebrain. J Neurosci 32(43):15012-26.
• Grégoire CA, Bonenfant D, Le Nguyen A, Aumont A, Fernandes KJL (2014). Untangling the influences of voluntary running, environmental complexity, social housing and stress on adult hippocampal neurogenesis. PLOS One 9(1):e86237.
• Lacroix S, Hamilton LK, Vaugeois A, Beaudoin S, Breault-Dugas C, Pineau I, Lévesque S, Grégoire C-A, Fernandes KJL (2014). Central canal ependymal cells proliferate extensively in response to traumatic spinal cord injury but not demyelinating lesions. PLOS One 9(1):e85916.
• Hamilton LK, Dufresne M, Joppé SE, Petryszyn S, Aumont A, Calon F, Barnabé-Heider F, Furtos A, Parent M, Chaurand P, Fernandes KJL (2015). Aberrant lipid metabolism in the forebrain niche suppresses adult neural stem cell proliferation in an animal model of Alzheimer’s disease. Cell Stem Cell 17(4):397-411.
• Joppé SE, Hamilton LK, Cochard LM, Levros LC, Aumont A, Barnabé-Heider F, Fernandes KJL (2015). BMP impinges on EGFR-induced proliferation signaling to maintain a quiescent neural stem cell pool. Front Neurosci 9:407.