Jean-Claude Lacaille

Thème (s)

• Organisation et fonction des circuits synaptiques de l’hippocampe;
• Plasticité de la transmission synaptique dans l’apprentissage et mémoire;
• Dysfonction synaptique dans les maladies du cerveau (autisme, déficience intellectuelle et l’épilepsie).

Publications choisies

• Asgarihafshejani, A., Honoré, È., Michon, F.-X., Laplante, I. and Lacaille, J.-C. Long-term potentiation at pyramidal cell to somatostatin interneuron synapses controls hippocampal network plasticity and memory. iScience 25:104259, 1-22, 2022.
• Honoré, E., Khlaifia, A., Bosson, A. and Lacaille, J.-C. Hippocampal somatostatin interneurons, long-term synaptic plasticity and memory. Frontiers in Neural Circuits 15:687558, 1-24, 2021.
• Sharma, V., Sood, R., Lou, D., Hung, T.Y., Lévesque, M., Han, Y., Levett, J., Wang, P., Murthy, S., Tansley, S., Wang, S., Siddiqui, N., Tahmasebi, S., Rosenblum, K., Avoli, M., Lacaille, J.-C., Sonenberg, N., Khoutorsky, A. 4E-BP2-dependent translation in parvalbumin neurons controls epileptic seizure threshold. Proceedings of the National Academy of Sciences (USA) 118 (15), 1-9, 2021.
• Aguilar-Valles, A., De Gregorio, D., Matta-Camacho, E., Eslamizade, M.J., Khlaifia, A., Skaleka, A., Lopez-Canul, M., Torres-Berrio, A., Bermudez, S., Rurak, G.M., Simard, S., Salmaso, N., Gobbi, G., Lacaille, J.-C. and Sonenberg, N. Antidepressant actions of ketamine engage cell-specific translation via eIF4E. Nature 590, 315-319, 2021.
• Sharma, V., Sood, R., Khlaifia, A., Eslamizade, M.J., Hung, T.-Y., Lou, D., Asgarihafshejani, A., Lalzar, M., Kiniry, S.J., Stokes, M.P., Cohen, N., Nelson, A.J., Abell, K., Possemato, A.P., Gal-Ben-Ari, S., Truong, V.T., Wang, P., Yiannakas, A., Saffarzadeh, F., Cuello, A.C., Nader, K., Kaufman, R.J., Costa-Mattioli, M., Baranov, P.V., Quintana, A., Sanz, E., Khoutorsky, A., Lacaille, J.-C., Rosenblum, K. and Sonenberg, N. eIF2α controls memory consolidation via excitatory and somatostatin neurons. Nature 586, 412-416, 2020.
• Matos, M., Bosson, A., Riebe, I., Reynell, C., Vallée, J., Laplante, I., Panatier, A., Robitaille*, R. and Lacaille*, J.-C.  Astrocytes detect and upregulate transmission at inhibitory synapses of somatostatin interneurons onto pyramidal cells. Nature Communications 9:4254, 1-15, 2018.

Publications

PubMed

Titulaire de la Chaire de recherche du Canada en neurophysiologie cellulaire et moléculaire:

Lien: http://www.chairs-chaires.gc.ca/chairholders-titulaires/profile-fra.aspx?profileId=379