Alex Parker

Thème (s)

• Modèles génétiques pour les maladies neurodégénératives chez C. elegans;
• Voies de réponse au stress dans les neurones;
• La découverte de médicaments pour la neurodégénérescence.

Publications choisies

• Deletion of C9ORF72 results in motor neuron degeneration and stress sensitivity in C. elegans. Therrien M, Rouleau GA, Dion PA,  Parker JA. PLoS One, Published: December 12, 2013DOI: 10.1371/journal.pone.0083450;
• Pharmacological reduction of ER stress protects against TDP-43 neuronal toxicity in vivo. Vaccaro A, Patten SA, Aggad D, Julien C, Maios C, Kabashi E, Drapeau P, Parker JA. Neurobiology of Disease, 2013, 55: 64–75;
• Evaluation of longevity enhancing compounds against TDP-43 neuronal toxicity. Tauffenberger A, Julien C, Parker JA. Neurobiology of Aging, 2013, First published online: April 13, 2013;
• Reduction of polyglutamine toxicity by TDP-43, FUS and Progranulin in Huntington’s Disease models. Tauffenberger A, Chitramuthu BP, Bateman A, Bennett HPJ, Parker JA. Human Molecular Genetics, 2012, doi: 10.1093/hmg/dds485, First published online: November 19, 2012;
• Integration of β-Catenin, Sirtuin, and FOXO Signaling Protects from Mutant Huntingtin Toxicity. Parker JA, Vazquez-Manrique RP, Tourette C, Farina F, Offner N, Mukhopadhyay A, Orfila AM, Darbois A, Menet S, Tissenbaum HA, Neri C. Journal of Neuroscience, 2012 Sep 5;32(36):12630-40;
• Methylene Blue Protects against TDP-43 and FUS Neuronal Toxicity in C. elegans and D. rerio. Vaccaro A, Patten SA, Ciura S, Maios C, Therrien M, Drapeau P, Kabashi E, Parker JA*. PLoS One, 2012;7(7):e42117. Epub 2012 Jul 27;
• TDP-1/TDP-43 Regulates Stress Signaling and Age-Dependent Proteotoxicity in C. elegans. Vaccaro A, Tauffenberger A, Ash PEA, Petrucelli L, Parker JA. PLoS Genetics, 2012 Jul;8(7):e1002806. Epub 2012 Jul 5;
• Glucose delays age-dependent proteotoxicity. Tauffenberger A, Vaccaro A, Aulas A, Vande Velde C, Parker JA. Aging Cell, 2012 Jun 26;
• Mutant TDP-43 and FUS cause age-dependent paralysis and neurodegeneration in C. elegans. Vaccaro A, Tauffenberger A, Aggad D, Rouleau G, Drapeau P, Parker JA. PLoS One, 2012;7(2):e31321. Epub 2012 Feb 21;
• Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons. Parker JA, Arango M, Abderrahmane S, Lambert E, Tourette C, Catoire H, Néri C. Nature Genetics 2005; 37 :349-50.