Jannic Boehm

Thème (s)

• Le rôle de la protéine précurseur de l’amyloïde dans la régulation de la plasticité synaptique;
• L’impact des protéines argonaute sur le développement neuronal;
• Les protéines impliquées dans le syndrome de Down et leur rôle dans la régulation de la plasticité synaptique.

Publications choisies

• Nicolas Paradis-Isler and Jannic Boehm. “NMDA-receptor dependent dephosphorylation of serine 387 in Argonaute 2 increases its degradation and affects dendritic spine density and maturation.” J Biol Chem. 2018 Jun 15;293(24):9311-9325.
• Emilie Trillaud-Doppia and Jannic Boehm. “The Amyloid Precursor Protein Intracellular Domain Is an Effector Molecule of Metaplasticity.” Biological Psychiatry, 2018 Mar 1;83(5):406-415.
• Emilie Trillaud-Doppia, Nicolas Paradis-Isler and Jannic Boehm. “A single amino acid difference between the intracellular domains of amyloid precursor protein and amyloid-like precursor protein 2 enables induction of synaptic depression and block of long-term potentiation.” Neurobiology of Disease, 2016 Jul; 91:94-104.
• Jannic Boehm. “A « danse macabre » : tau and Fyn in STEP with amyloid-beta to facilitate induction of synaptic depression and excitotoxicity.” Eur J Neurosci., 2013 Jun; 37(12) :1925-30.
• Albert Tamburri, Anthony Dudilot, Sara Licea, Catherine Bourgeois and Jannic Boehm. NMDA-Receceptor “Activation but Not Ion Flux Is Required for Amyloid-Beta Induced Synaptic Depression.” PLOS One, 2013 Jun 4; 8(6):e65350.
• Siddhartha Mondragon-Rodriguez, Emilie Trillaud-Doppia, Anthony Dudilot, Catherine Bourgeois, Michel Lauzon, Nicole Leclerc and Jannic Boehm. “Interaction of endogenous tau with synaptic proteins is regulated by NMDA-receptor dependent tau phosphorylation.” J Biol Chem., 2012 Sept 14; 287 (38): 32040-32053.