Valérie Mongrain

Thème (s)

• La régulation moléculaire du sommeil et des rythmes biologiques;
• Liens entre homéostasie du sommeil et plasticité neuronale et implication des protéines d’adhésion cellulaire dans la régulation du sommeil;
• Associations entre troubles du sommeil et conditions psychiatriques ou neurologiques.

Publications choisies

• Ballester Roig MN, Mongrain V. Sleep-inducing effect of Rhynchophylline in EphA4 knockout mice. SLEEP Advances 2023:4(1):zpad037. https://doi.org/10.1093/sleepadvances/zpad037
• Hector A, Provost C, Delignat-Lavaud B, Bouamira K, Menaouar CA, Mongrain V, Brouillette J. Hippocampal injections of soluble amyloid-beta oligomers alter electroencephalographic activity during wake and slow-wave sleep in rats. Alzheimer’s Research & Therapy 2023:15;174.https://doi.org/10.1186/s13195-023-01316-4
• Dib R, Gervais NJ, Mongrain V. A review of the current state of knowledge on sex differences in sleep and circadian phenotypes in rodents. Neurobiol Sleep Circadian Rhythms 2021, 11, 100068. doi: 10.1016/j.nbscr.2021.100068.
• Dufort-Gervais J, Havekes R, Mongrain V. Electrocorticographic recording of cerebral cortex areas manipulated using an adeno-associated virus targeting Cofilin in mice. J Vis Exp 2021, (168). doi: 10.3791/61976.
• Khlghatyan J, Evstratova A, Bozoyan L, Chamberland S, Chatterjee D, Marakhovskaia A, Soares Silva T, Toth K, Mongrain V, Beaulieu JM. Fxr1 regulates sleep and synaptic homeostasis. EMBO J 2020, 39(21), e103864. doi: 10.15252/embj.2019103864.
• Dufort-Gervais J, Provost C, Charbonneau L, Norris CM, Calon F, Mongrain V, Brouillette J. Neuroligin-1 is altered in the hippocampus of Alzheimer’s disease patients and mouse models, and modulates the toxicity of amyloid-beta oligomers. Sci Rep 2020, 10(1), 6956. doi: 10.1038/s41598-020-63255-6.
• Areal CC, Cao R, Sonenberg N, Mongrain V. Wakefulness/sleep architecture and electroencephalographic activity in mice lacking the translational repressor 4E-BP1 or 4E-BP2. Sleep, 2020, 43(2), zsz210. doi: 10.1093/sleep/zsz210.
• Hannou L, Roy PG, Ballester Roig MN, Mongrain V. Transcriptional control of synaptic components by the clock machinery. Eur J Neurosci 2020, 51(1), 241-267. doi: 10.1111/ejn.14294.
• Hannou L, Bélanger-Nelson E, O’Callaghan EK, Dufort-Gervais J, Ballester Roig MN, Roy PG, Beaulieu JM, Cermakian N, Mongrain V. Regulation of the Neuroligin-1 gene by clock transcription factors. J Biol Rhythms 2018, 33(2), 166-178. doi: 10.1177/0748730418761236.
• Areal CC, Warby SC, Mongrain V. Sleep loss and structural plasticity. Curr Opin Neurobiol 2017, 44, 1-7.
• Bedont JL, LeGates TA, Buhr E, Bathini A, Ling JP, Bell B, Wu MN, Wong PC, Van Gelder RN, Mongrain V, Hattar S, Blackshaw S. An LHX1-Regulated Transcriptional Network Controls Sleep/Wake Coupling and Thermal Resistance of the Central Circadian Clockworks. Curr Biol 2017, 27(1), 128-136.
• O’Callaghan EK, Ballester Roig MN, Mongrain V. Cell adhesion molecules and sleep. Neurosci Res 2017, 116, 29-38.
• Freyburger M, Pierre A, Paquette G, Bélanger-Nelson E, Bedont J, Gaudreault PO, Drolet G, Laforest S, Blackshaw S, Cermakian N, Doucet G, Mongrain V. EphA4 is involved in sleep regulation but not in the electrophysiological response to sleep deprivation. Sleep 2016, 39(3), 613-624.
• Sabir M, Gaudreault PO, Freyburger M, Massart R, Blanchet-Cohen A, Jaber M, Gosselin N, Mongrain V. Impact of traumatic brain injury on sleep structure, electrocorticographic activity and transcriptome in mice. Brain Behav Immun 2015, 47, 118-130.
• Massart R, Freyburger M, Suderman M, Paquet J, El Helou J, Bélanger-Nelson E, Rachalski A, Koumar OC, Carrier J, Szyf M, Mongrain V. The genome-wide landscape of DNA methylation and hydroxymethylation in response to sleep deprivation impacts on synaptic plasticity genes. Transl Psychiatry 2014, 4, e347.
• El Helou J, Bélanger-Nelson E, Freyburger M, Dorsaz S, Curie T, La Spada F, Gaudreault PO, Beaumont É, Pouliot P, Lesage F Frank MG, Franken P, Mongrain V. Neuroligin-1 links neuronal activity to sleep-wake regulation. PNAS USA 2013, 110(24), 9974-9979.