Antoine Duquette

Thème (s)

• Ataxies spinocérébelleuses et ataxie de Friedreich : histoire naturelle, essais cliniques, réalité virtuelle;
• Paralysie supranucléaire progressive et parkinsonisme: marqueurs diagnostiques et de progression, essais cliniques.

Publications choisies

• Duquette A, Roddier K, McNabb J, Gosselin I, St-Denis A, Dicaire MJ, Loisel L, Labuda D, Marchand L, Mathieu J, Bouchard JP, Brais B. Mutations in senataxin responsible for a French-Canadian cluster of spinocerebellar ataxia without ocular apraxia. Annals of Neurology, 2005 Feb;57(3)408-414.
• Duquette A, Brais B, Bouchard JP, Mathieu J. Clinical presentation and early evolution of spastic ataxia of Charlevoix-Saguenay (ARSACS). Movement Disorders, 2013 Dec ; 28(14):2011-2014.
• Pernègre C, Duquette A, Leclerc N. Tau secretion: good and bad for neurons. Frontiers Neuroscience. Frontiers in Neuroscience. 2019 Jun; 13 : 649.
• Duquette A, Pernègre C, Veilleux Carpentier A, Leclerc N. Similarities and differences in the pattern of tau hyperphosphorylation in physiological and pathological conditions: impacts on the elaboration of therapies to prevent tau pathology. Frontiers in Neurology. 2020 11:607680.
• Höglinger G, Litvan I, Mendonca N, et al. Safety and efficacy of tilavonemab in progressive supranuclear palsy: a phase 2, randomized, placebo-controlled trial. The Lancet Neurology, 2021 Mar;20(3):182-192.
• Touma L, Labrecque M, Tetreault M*, Duquette A*. Identification and classification of rare variants in NPC1 and NPC2 in Quebec. Scientific Reports, 2021; 11(1):1-8.
• Labrecque M, Touma L, Bherer C, Duquette A*, Tetreault M*. Estimated prevalence of Niemann-Pick type C disease in Quebec. Scientific Reports, 2021;11:22621.