Graziella Di Cristo

Thème (s)

• Voies moléculaires impliquées dans la maturation des circuits GABAergiques dans le cerveau postnatal ;
• Plasticité des circuits corticaux en développement ;
• Troubles d’apprentissage dans des modèles animaux de maladies neurodéveloppementales (déficience intellectuelle, autisme).

Publications choisies

• Di Cristo G, Chattopadhyaya B, Kuhlman SJ, Fu Y, Bélanger M-C, Wu CZ Rutishauser U, Maffei L, Huang ZJ (2007). Activity-dependent PSA expression promotes the maturation of GABA inhibition and the onset of critical period plasticity. Nature Neuroscience, 10:1569-1577.
• Baho E, Di Cristo G (2012). Neural activity and neurotransmission regulate the maturation of innervation field of cortical GABAergic interneurons in an age-dependent manner. Journal of Neuroscience,  32: 911-918.
• Chattopadhyaya B, Baho E, Huang JZ, Schachner M, Di Cristo G (2013). Neural cell adhesion molecule-mediated Fyn activation promotes GABAergic synapse maturation in postnatal mouse cortex. Journal of Neuroscience, 33: 5957-68.
• Berryer MH, Hamdan FF, Klitten LL, Møller RS, Carmant L, Schwartzentruber J, Patry L, Dobrzeniecka S, Rochefort D, Neugnot-Cerioli M, Lacaille JC, Niu Z, Eng CM, Yang Y, Palardy S, Belhumeur C, Rouleau GA, Tommerup N, Immken L, Beauchamp MH, Patel GS, Majewski J, Tarnopolsky MA, Scheffzek K, Hjalgrim H, Michaud JL*, Di Cristo G* (2013). Mutations in SYNGAP1 cause intellectual disability, autism and a specific form of epilepsy by inducing haploinsufficiency. Human Mutations, 34:385-94. *corresponding authors.
• Awad PN, Sanon N, Chattopadhyaya B, Carriço JN, Ouardouz M, Gagné J, Duss S, Wolf D, Desgent S, Cancedda L, Carmant L, Di Cristo G (2016). Reducing premature KCC2 expression rescues seizure susceptibility and spine morphology in atypical febrile seizures. Neurobiology of Diseases, 91:10-20.
• Berryer MH, Chattopadhyaya B, Xing P, Riebe I, Bosoi C, Sanon N, Antoine-Bertrand J, Lévesque M, Avoli M, Hamdan FF, Carmant L, Lamarche-Vane N, Lacaille JC, Michaud JL*, Di Cristo G* (2016). Decrease of SYNGAP1 in GABAergic cells impairs inhibitory synapse connectivity, synaptic inhibition and cognitive function. Nature Communications, 7:13340. *corresponding authors.
• Di Cristo G, Awad PN, Hamidi S, Avoli M (2018). KCC2, Epileptiform Synchronization and Epileptic Disorders. Progress in Neurobiology, 162:1-6.
• Awad PN, Amegandjin CA, Szczurkowska J, Nunes-Carriço J, Baho E, Cancedda L, Carmant L, Di Cristo G (2018). The effects of KCC2 on dendritic spine formation are cortical-region and BDNF dependent. Cerebral Cortex, 28: 4049-4062.
• Baho E*, Chattopadhyaya B*, Lavertu-Jolin M*, Mazziotti R, Awad PN, Chehrazi P, Groleau M, Jahannault-Talignani C, Sanon NT, Vaucher E, Ango F, Pizzorusso T, Baroncelli L, Di Cristo G (2019). P75 Neurotrophin Receptor regulates the timing of maturation of cortical parvalbumin cell connectivity and promotes ocular dominance plasticity in adult visual cortex. Journal of Neuroscience, 39: 4489-4510. * equally contributing authors.
• Patrizi A, Awad PN*, Chattopadhyaya B*, Di Cristo G, Fagiolini M (2020). Accelerated hyper maturation of parvalbumin circuits in the absence of MeCP2. Cerebral Cortex, 30:256-268. *equally contributing authors.
• Amegandjin CA*, Choudhury M*,  Jadhav V, Nunes-Carrico J, Quintal A, Berryer MH, Snapyan M, Chattopadhyaya B, Saghatelyan A, Di Cristo G (2021). mTOR inhibition restricted to a postnatal sensitive period rescues the deficits in GABAergic PV cell connectivity and social behavior caused by loss of Tsc1. Nature Communications, 12:3653. *equally contributing authors.
• Di Cristo G, Chattopadhyaya B (2021). Development of neuronal circuits: From synaptogenesis to synapse plasticity. Handbook of clinical neurology, 173:43-53.
• Pará C, Bose P, Bruno L, Freemantle E, Taherzadeh M, Pan X, Han C, McPherson PS, Lacaille JC, Bonneil É, Thibault P, O’Leary C, Bigger B, Morales CR, Di Cristo G, Pshezhetsky AV (2021). Early defects in mucopolysaccharidosis type IIIC disrupt excitatory synaptic transmission. Journal of Clinical Investigation Insight. 6(15):e142073.
• Shaker T, Chattopadhyaya B, Amilhon B, Di Cristo G, Weil AG (2021). Transduction of inflammation from peripheral immune cells to the hippocampus induces neuronal hyperexcitability mediated by Caspase-1 activation. Neurobiology of Diseases, 160:105535.
• Munguba H, Chattopadhyaya B, Nilsson S, Carriço JN, Memic F, Oberst P, Batista-Brito R, Muñoz-Manchado AB, Wegner M, Fishell G, Di Cristo G*, Hjerling-Leffler J* (2021). Postnatal Sox6 Regulates Synaptic Function of Cortical Parvalbumin-Expressing Neurons. Journal of Neuroscience, 41:8876-8886. *corresponding authors.
• Mirabella F, Desiato G, Mancinelli S, Fossati G, Rasile M, Morini R, Markicevic M, Grimm C, Amegandjin C, Termanini A, Peano C, Kunderfranco P, Di Cristo G, Zerbi V, Menna E, Lodato S, Matteoli M, Pozzi D (2021). Prenatal interleukin 6 elevation increases glutamatergic synapse density and disrupts hippocampal connectivity in offspring. Immunity, 54:2611-2631.
• Carreño-Muñoz MI, Chattopadhyaya B, Agbogba K, Côté V, Wang S, Lévesque M, Avoli M, Michaud JL, Lippé S*, Di Cristo G*(2022). Sensory processing dysregulations as reliable translational biomarkers in SYNGAP1 haploinsufficiency. Brain, 145: 754-769. doi: 10.1093/brain/awab329. *corresponding authors.
• Cherubini E, Di Cristo G, Avoli M.  (2022). Dysregulation of GABAergic Signaling in Neurodevelomental Disorders: Targeting Cation-Chloride Co-transporters to Re-establish a Proper E/I Balance. Front Cell Neurosci. 15:813441.
• Wolf DC, Sanon NT, Cunha AOS, Chen JS, Shaker T, Elhassan AR, do Nascimento ASF, Di Cristo G, Weil AG (2022). Sex-specific differences in KCC2 localisation and inhibitory synaptic transmission in the rat hippocampus. Science Rep 12:3186.