Kessen Patten

Thème (s)

• Le dysfonctionnement des synapses dans les maladies des motoneurones tel que la sclérose latérale amyotrophique (SLA) et l’atrophie spinale ;
• Rôle des gènes de remodelage de la chromatine dans le développement du cerveau et les maladies du néurodéveloppement (e.g syndrome de CHARGE, troubles du spectre autistique) ;
• Crible de médicaments dans des modèles génétiques de maladies neurodégénératives et neurodéveloppementales.

Publications choisies

• Jamadagni P, Breuer M, Schmeisser K, Cardinal T, Kassa B, Pilon N, Parker JA, Samarut E and Patten SA. CHD7 controls GABAergic neuron development by promoting PAQR3 expression (2021); EMBO reports, Jun 4;22(6):e50958.
• Butti Z, Pan YE, Giacomotto J and Patten SA. Reduced C9orf72 function leads to defective synaptic vesicle release and neuromuscular dysfunction in zebrafish. (2021); Communications Biology, Jun 25;4(1):792.
• Rabanel JM, Faivre J, Zaouter C, Patten SA, Banquy X, Ramassamy C. (2021). Nanoparticle shell structural cues drive in vitro transport properties, tissue distribution and brain accessibility in zebrafish; Biomaterials, 277: 121085.
• Liu J, Zaouter C, Liu X, Patten SA, and Liang J. Coded-aperture broadbrand light field using digital micromirror devices (2021); Optica 8(2), 139-142.
• Fortier G, Butti Z and Patten SA. Modelling C9or72-related amyotrophic lateral sclerosis in zebrafish. (2020). Biomedicines, Oct 21;8(10):440.
• Rabanel JM, Piec PA, Landri S, Patten SA, and Ramassamy C. Transport of PEGylated-PLA nanoparticles across a blood brain barrier model, entry into neuronal cells and in vivo brain bioavailability. (2020); Journal of Controlled Released, Dec 10; 328:679-695.
• Poujol de Molliens M, Jamadagni P, Létourneau M, Devost D, Hébert TE, Patten SA, Fournier A, Chatenet D. Design and biological assessment of membrane-tethering neuroprotective peptides derived from the pituitary adenylate cyclase-activating polypeptide type 1 receptor. Biochim Biophys Acta Gen Subj.1863(11)::1293 (2019).
• Patten SA, Aggad D, Martinez J, Tremblay E, Petrillo J, Armstrong GAB, LaFontaine A, Maios C, Liao M, Ciura S, Wen XY, Rafuse V, Ichida J, Zinman L, Julien JP, Kabashi E, Robitaille R, Korngut L, Parker JA,Drapeau P. Neuroleptics as therapeutic compounds stabilizing neuromuscular transmission in amyotrophiclateral sclerosis (2017); Journal of Clinical Investigation insight  16:2(22).