Valérie Mongrain

Valerie-Mongrain

Professeure agrégée
Chaire de recherche du Canada en physiologie moléculaire du sommeil
514 338-2222, poste 3323
514 338-2694 (télécopieur)
Courriel – Site Web

Adresse physique
Centre de recherche, bureau K-3055
Hôpital du Sacré-Cœur de Montréal
Recherche CIUSSS-NIM
5400 boul. Gouin Ouest
Montréal (Québec) H4J1C5

Adresse postale
Département de neurosciences
Faculté de médecine
Université de Montréal
C.P. 6128, Succ. Centre-ville
Montréal (Québec) H3C 3J7


Thème (s)

  • La régulation moléculaire du sommeil et des rythmes biologiques;
  • Liens entre homéostasie du sommeil et plasticité neuronale et implication des protéines d’adhésion cellulaire dans la régulation du sommeil;
  • Associations entre troubles du sommeil et conditions psychiatriques ou neurologiques.

Publications choisies

  • Dib R, Gervais NJ, Mongrain V. A review of the current state of knowledge on sex differences in sleep and circadian phenotypes in rodents. Neurobiol Sleep Circadian Rhythms 2021, 11, 100068. doi: 10.1016/j.nbscr.2021.100068.
  • Dufort-Gervais J, Havekes R, Mongrain V. Electrocorticographic recording of cerebral cortex areas manipulated using an adeno-associated virus targeting Cofilin in mice. J Vis Exp 2021, (168). doi: 10.3791/61976.
  • Khlghatyan J, Evstratova A, Bozoyan L, Chamberland S, Chatterjee D, Marakhovskaia A, Soares Silva T, Toth K, Mongrain V, Beaulieu JM. Fxr1 regulates sleep and synaptic homeostasis. EMBO J 2020, 39(21), e103864. doi: 10.15252/embj.2019103864.
  • Dufort-Gervais J, Provost C, Charbonneau L, Norris CM, Calon F, Mongrain V, Brouillette J. Neuroligin-1 is altered in the hippocampus of Alzheimer’s disease patients and mouse models, and modulates the toxicity of amyloid-beta oligomers. Sci Rep 2020, 10(1), 6956. doi: 10.1038/s41598-020-63255-6.
  • Areal CC, Cao R, Sonenberg N, Mongrain V. Wakefulness/sleep architecture and electroencephalographic activity in mice lacking the translational repressor 4E-BP1 or 4E-BP2. Sleep, 2020, 43(2), zsz210. doi: 10.1093/sleep/zsz210.
  • Hannou L, Roy PG, Ballester Roig MN, Mongrain V. Transcriptional control of synaptic components by the clock machinery. Eur J Neurosci 2020, 51(1), 241-267. doi: 10.1111/ejn.14294.
  • Hannou L, Bélanger-Nelson E, O’Callaghan EK, Dufort-Gervais J, Ballester Roig MN, Roy PG, Beaulieu JM, Cermakian N, Mongrain V. Regulation of the Neuroligin-1 gene by clock transcription factors. J Biol Rhythms 2018, 33(2), 166-178. doi: 10.1177/0748730418761236.
  • Areal CC, Warby SC, Mongrain V. Sleep loss and structural plasticity. Curr Opin Neurobiol 2017, 44, 1-7.
  • Bedont JL, LeGates TA, Buhr E, Bathini A, Ling JP, Bell B, Wu MN, Wong PC, Van Gelder RN, Mongrain V, Hattar S, Blackshaw S. An LHX1-Regulated Transcriptional Network Controls Sleep/Wake Coupling and Thermal Resistance of the Central Circadian Clockworks. Curr Biol 2017, 27(1), 128-136.
  • O’Callaghan EK, Ballester Roig MN, Mongrain V. Cell adhesion molecules and sleep. Neurosci Res 2017, 116, 29-38.
  • Freyburger M, Pierre A, Paquette G, Bélanger-Nelson E, Bedont J, Gaudreault PO, Drolet G, Laforest S, Blackshaw S, Cermakian N, Doucet G, Mongrain V. EphA4 is involved in sleep regulation but not in the electrophysiological response to sleep deprivation. Sleep 2016, 39(3), 613-624.
  • Sabir M, Gaudreault PO, Freyburger M, Massart R, Blanchet-Cohen A, Jaber M, Gosselin N, Mongrain V. Impact of traumatic brain injury on sleep structure, electrocorticographic activity and transcriptome in mice. Brain Behav Immun 2015, 47, 118-130.
  • Massart R, Freyburger M, Suderman M, Paquet J, El Helou J, Bélanger-Nelson E, Rachalski A, Koumar OC, Carrier J, Szyf M, Mongrain V. The genome-wide landscape of DNA methylation and hydroxymethylation in response to sleep deprivation impacts on synaptic plasticity genes. Transl Psychiatry 2014, 4, e347.
  • El Helou J, Bélanger-Nelson E, Freyburger M, Dorsaz S, Curie T, La Spada F, Gaudreault PO, Beaumont É, Pouliot P, Lesage F Frank MG, Franken P, Mongrain V. Neuroligin-1 links neuronal activity to sleep-wake regulation. PNAS USA 2013, 110(24), 9974-9979.