Roberto Araya

Thème (s)

• Intégration synaptique des neurones pyramidaux néocorticaux;
• Structure et fonction des épines dendritiques et leur rôle dans le traitement de l’information et la plasticité des circuits corticaux;
• Application des règles d’apprentissage des épines dendritiques à l’intelligence artificielle;
• Rôle d’épissage de l’ARN des canaux ioniques sur la physiologie et le développement synaptique.

Publications choisies

• Tazerart S, Mitchell DE, Miranda-Rottmann S, Araya R. A spike-timing-dependent plasticity rule for dendritic spines. Nat Commun. 2020;11(1):4276. Published 2020 Aug 26. doi:10.1038/s41467-020-17861-7;
• Mitchell DE, Martineau É, Tazerart S, Araya R. Probing Single Synapses via the Photolytic Release of Neurotransmitters. Front Synaptic Neurosci. 2019 Jul 12;11:19. doi: 10.3389/fnsyn.2019.00019. PMID: 31354469; PMCID: PMC6640007;
• Jiang X, Lupien-Meilleur A, Tazerart S, Lachance M, Samarova E, Araya R, Lacaille JC, Rossignol E. Remodeled cortical inhibition prevents motor seizures in generalized epilepsy. Ann Neurol. 2018 Sep;84(3):436-451. doi: 10.1002/ana.25301. PMID: 30048010;
• Opazo JC, Zavala K, Miranda-Rottmann S, Araya R. Evolution of dopamine receptors: phylogenetic evidence suggests a later origin of the DRD_2l and DRD_4rs dopamine receptor gene lineages. PeerJ. 2018 Apr 13;6:e4593. doi: 10.7717/peerj.4593. PMID: 29666757; PMCID: PMC5900934;
• Saito Y, Miranda-Rottmann S, Ruggiu M, Park CY, Fak JJ, Zhong R, Duncan JS, Fabella BA, Junge HJ, Chen Z, Araya R, Fritzsch B, Hudspeth AJ, Darnell RB. NOVA2-mediated RNA regulation is required for axonal pathfinding during development. Elife. 2016 May 25;5:e14371. doi: 10.7554/eLife.14371. PMID: 27223325; PMCID: PMC4930328;
• Araya R, Vogels TP, Yuste R. Activity-dependent dendritic spine neck changes are correlated with synaptic strength. Proc Natl Acad Sci U S A. 2014 Jul 15;111(28):E2895-904. doi: 10.1073/pnas.1321869111. Epub 2014 Jun 30. PMID: 24982196; PMCID: PMC4104910;
• Araya R, Input transformation by dendritic spines of pyramidal neurons.Front. Neuroanat. (2014). doi: 10.3389/fnana.2014.00141;
• Araya R, Andino-Pavlovsky V, Yuste R, Etchenique R. Two-photon optical interrogation of individual dendritic spines with caged dopamine. ACS Chem Neurosci. (2013) 21;4(8):1163-7;
• Watson BO, Nikolenko V, Araya R, Peterka DS, Woodruff A, Yuste R.  Two-photon microscopy with diffractive optical elements and spatial light modulators. Frontiers in Neuroscience. (2010) 15;4;
• Fino E, Araya R, Peterka, D S, Salierno M, Etchenique R, Yuste R.  RuBi-Glutamate: Two-photon and visible-light photoactivation of neurons and dendritic spines. Frontiers in Neural Circuits. (2009) 3:2;
• Nikolenko V, Watson B O, Araya R, Woodruff A, Peterka D S, Yuste R. SLM Microscopy: Scanless Two-photon Imaging and Photostimulation using Spatial Light Modulators. Frontiers in Neural Circuits. (2008) 2: 5;
• Araya R, Nikolenko V, Eisenthal KB, Yuste R. Spine sodium channels amplify spine potentials. Proc Natl Acad Sci U S A. (2007) 104:12347-52;
• Araya R, Eisenthal KB, Yuste R. Dendritic spines linearize the summation of excitatory potentials. Proc Natl Acad Sci U S A. (2006) 103:18799-804.